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Science

Publications

Metagenomic Analysis using Real-Time DNA Sequencing Analysis as a Diagnostic Tool for Naturally-Occuring Urinary Tract Infections in Dogs

Comparative Microbiome Analysis of Cohabiting Wildlife Species with Disease Vector Potential: Canada Geese vs. Domestic Flies

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McDonald et al. showed that patients with acute cystitis had significantly improved symptom scores when their treatment was based on DNA NGS results versus traditional culture and sensitivity. 100% of patients showed positive results in DNA NGS, while only 30% patients had positive urine culture and sensitivity results.

McDonald et al. Rev Urol. 2017; 19(4):213-220. doi:10.3909/riu0780

NGS aids diagnosis and treatment of acute cystitis

Impact of Prophylactic Antibiotics on Canine Fecal Microbiome in Orthopedic Emergency Cases

Effect of Carotenoid Dietary Supplementation on the Cutaneous Microbiome in Captive Golden Dart Frogs (Phyllobates terribilis)

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Rodrigues Hoffmann et al. identified a large amount of previously uncultured or rarely isolated microbes in the skin of dogs. The skin of dogs is inhabited by much more rich and diverse microbial communities than was previously thought based on culture-based methods.

Rodrigues Hoffmann et al. PloS one 2014; 9.1,e83197

NGS shows less bacterial species richness in allergic dogs vs healthy dogs

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Pierezan et al. showed that allergen challenge in  dogs is associated with a bacterial dysbiosis during the development of skin lesions and S. pseud-intermedius plays an important role in this dysbiosis.

Pierezan et al. Vet Dermatol. 2016; 27:332-e82. doi:10.1111/vde.12366

NGS points at bacterial dysbiosis in allergen-induced canine atopic dermatitis

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Kirchoff et al. report in their recent publication data that supports that there is link between the presence and abundance of certain gut bacteria and different behavioral traits in Pit Bull type dogs. 

Kirchoff et al. PeerJ 2019; 7:e6103

NGS links canine gut microbiome to behavioral traits

According to Weinstock et al. NGS has the potential to"revolutionize the clinical microbiology laboratory by replacing current time-consuming and labor-intensive techniques with a single, all-inclusive diagnostic test."

Weinstock et al. 2016; Applications of clinical microbial next-generation sequencing.

NGS provides clinically actionable results

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Goldberg et al. review the challenges and opportunities of NGS based clinical diagnostics.

Goldberg et al. mBio 2015; 6(6):e01888-15. doi:10.1128/mBio.01888-15

NGS in infectious disease diagnostics and pathogen analysis

Other publications highlighting the importance of DNA based diagnostics:

The bacteria in canine plaque are very different from human bacteria and appear to warrant a different medical treatment to fight against periodontitis. 

Wallis et al.  Veterinary Microbiology 2015; 181:271-282

NGS links the oral microbiome to periodontal disease in dogs

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The oral microbiome is quite different between humans and dogs as we share only about 16% of our oral bacteria with dogs. The canine oral cavity is characterized by a rich and diverse bacterial community and Dewhirst et al. discovered several unnamed bacterial taxa.

Dewhirst et al. PloS One 2012; 7(4):e36067

Discovery of novel canine oral bacteria with the help of NGS