Prevent total ear canal ablation in dogs

New research using MiDOG technology unveils possible new solution to total ear canal ablation.

Listen up! Could the latest research be a new solution to a very painful ear condition?

Dog ear infections are very common and as many as 20% of dogs have at least one ear infection during their lifetime. Prevention is key, involving regular visits to the veterinarian and appropriate cleaning of the ear and ear canals. Just like any other location of the dog’s body, the ear has a unique microbiome comprised of bacteria and fungi. These microbes can form a protective banner and most of them are typically commensals. But in some cases, they can cause painful infections. Chronic ear infections can result in a complete change in this microbiome, also called dysbiosis.

So far very little is known about what exactly such a microbial dysbiosis looks like and how it compares to a normal healthy dog ear. Many of those microbes are difficult to grow in the laboratory as they may take several weeks to grow on the artificial media like fungi for example, or they don’t grow when oxygen is present.

In a collaboration between Texas A&M University and MiDOG LLC, researchers conducted a study to identify the microbial makeup of dog ears in health and disease. Understanding the microbial ecology of the ears is very crucial in order to understand how ear infections evolve, how they can be best treated, and how they could be caught even before they are causing any pain to the patient.

As many of these bacteria and fungi don’t grow in the laboratory, they used a new tool: Next-Gen Sequencing. This allows for the accurate identification and quantification of all bacteria and fungi that are present in the dog’s ear at once. No matter how slow they grow or if we don’t know how to grow them in a laboratory at all.

“We were able to see that the ears of clinically affected dogs have a less rich microbial diversity when compared to healthy dogs,” said Dr. Marc Van Eden, one of the researchers in the publication published in Veterinary Microbiology in June 2020. “We saw a high abundance of fungi as well as bacteria, yet standard veterinary clinical diagnosis more often than not only includes bacterial culture testing. Therefore, the fungal population is often completely overlooked.”

In addition to the fungal population, the team was able to characterize a potential opportunistic pathogen that was previously not described in ear infections.

“Having such an unprecedented large data set of hundreds of healthy and clinically affected ears, allowed us to use different algorithms to identify members of the microbiome that are specifically enriched in diseased ears”’ said Dr. Krumbeck, senior author of the study. “This way we were able to identify Finegoldia magna as a novel, potentially very important player in canine ear infections.”

The team of researchers in this study concluded that this type of NGS-based microbial analysis will be the next gold standard to characterize ear infections in veterinary medicine.

This new technology has already proven that it worked better than traditional culture! Read here about little Heidi, who almost had a bilateral Total Ear Canal Ablation (TECA), a painful surgery to remove her ear canals on both sides. It turned out that she didn’t have a bacterial infection, but a fungal infection that was diagnosed with the help of the MiDOG All-in-One Test. Read more about her story here.

Categories: Dogs, Ear Health

animal diagnostics

Validated by Veterinarians

“Clients expect their veterinarians to stay up to date on all matters that affect the health and well being of their non-human family members. The current technique that we have used to determine the presence and antibiotic sensitivity of organisms causing disease in our pets is over a century old.

With the emergence of dangerous antibacterial resistance, it is critical that veterinarians are able to offer laser focused diagnostics and treatment. MiDog enables us to offer care that exceeds the typical standard of care.”

Bernadine Cruz, DVM, Laguna Hills Animal Hospital Laguna Woods, CA

“I love the absolute abundance and comparing the fungal with bacterial infection. I do not worry as much about getting a false negative urinary infection reading as I do with traditional urine cultures. Several times the same urine would culture negative but MiDOG would detect pathogens.”

Michael Morgan, DVMQuail Animal Hospital, Tustin, CA

“The MiDOG All-in-One Test is amazing, I would use it instead of culture and sensitivity.  Such rapid and detailed results, I will reach for MiDOG before culture next time!

Thank you very much MiDOG, for sharing the opportunity to try your technology.”

Martha Smith-Blackmore, DVM, President of Forensic Veterinary Investigations, LLC – Boston, MA

The MiDOG All-in-One Microbial Test is our new gold standard of pathogen identification. The results are so accurate and valuable – especially with assessing both bacterial and fungal infections with the same sample.

Thank you MiDOG!”

Kathy Wentworth, DVM, Diplomate ABVP Canine and Feline Practice – PetPoint Medical Center, Irvine, CA

“The MiDOG staff was extremely helpful and supportive.”

Cathy Curtis, DVM – London, UK

“I have had great results using the MiDOG® Test. Compared to traditional culture tests, I am better able to target the treatment for dogs because the MiDOG® Test is so sensitive that it identifies all pathogens including bacteria and fungi, as well as antibiotic sensitivity.

The cost and turnaround time are about the same as a culture test, but I get much more data. The test has great performance and I believe the NGS technology will be a game changer for veterinarians treating dogs with lesions or other infections.”

Michael Kavanagh, DVM, Practice owner – Saddleback Animal Hospital, Tustin, CA

“It’s helpful to have an NGS spectrum because it gives you a broader insight of what’s happening and what might be going on.”

Richard Harvey BVSc DVD DipECVD PhD FRSB FRCVS – European Specialist in Veterinary Dermatology – Head of Dermatology, Willows Veterinary Centre & Referral Service – Solihull, England UK

“I have been using MiDog for over 4 years now and exclusively as my test of choice for all cultures for 3 years.  It is so great to submit a culture and feel confident there will be a result when it comes back, especially for urine cultures.  The reports were intimidating at first because they contain so much information.  After the first few, I am now quickly able to glance over it and pick out the highlights.  I can then come back later and pour over all the details.  I have been extremely pleased with my patients’ results using the test as well.  I don’t envision ever going back to traditional culture and susceptibilities again.”

Brian M. Urmson, DVM, Columbiana Veterinary Associates

“As an exotic veterinarian, there are numerous tests we have to consider to check specific bacterial and fungal organisms based on the species. MiDOG eliminates the need for many of these separate samples and provides definitive results quickly to help us treat our patients more efficiently and effectively. The lab is wonderful to work with and has never rejected our samples- they even processed a lizard toe we amputated and determined the cause of skin infection.”

Dr. Melissa Giese, Chicago Exotics Animal Hospital

“MiDOG’s diagnostic approach offers the unique ability to identify pathogens that evade traditional culture and sensitivity testing. I have found that adding a molecular based testing approach in the form of Next Generation Sequencing (NGS) from MiDOG to my routine diagnostic cultures can be extremely helpful in the identification and diagnosis of uncommon pathogens in veterinary medicine.”

Dr. Wayne Rosenkrantz, Animal Dermatology Clinic – Tustin

“She [Dr. Krumbeck] really did a great job of making complicated concepts accessible and demonstrating the value of your services. I’m really looking forward to working with MiDOG on my research project!”

Dr. Yaicha Peters, Animal Dermatology Clinic – San Diego

“As a proud collaborator with MiDOG, I deeply appreciate their dedication to fostering partnerships between industry and veterinary experts. Their commitment to enhancing diagnostic quality for veterinarians is commendable. In my experience, their support has been invaluable, earning them a ‘Double A+, Triple Star’ rating. Their assistance has been faultless, contributing significantly to the success of my projects and studies. I eagerly anticipate our continued collaboration.”

Dr. Richard Harvey, BVSc DVD DipECVD PhD FRSB FRCVS; European Specialist in Veterinary Dermatology

“We’re seeing that, if we prescribe too many antibiotics or they’re taken too frequently, animals are developing inappropriate or pathogenic strains of bacteria. We’re also seeing that our antibiotics are just not working against them anymore… It’s a good example of why we need better diagnostic testing, like MiDOG, so that we’re selecting the correct antibiotic every time our patients have an infection.”

Dr. Alissa Rexo, DVM, CVA, DACVD, Mid-Atlantic Veterinary Dermatology

“The NGS technique as offered by MiDOG is wonderful because pathogens like Melissococcus plutonius, for example, are difficult to grow and keep alive in the laboratory. A standard laboratory cannot truly examine or even properly diagnose this pathogen in bee hives at this time. But with NGS, we can reliably diagnose it.”

Dr. Joerg Mayer, Entomologist and Microbiologist at the University of Georgia

“For me, as a clinician and as a researcher, I see the immense value in the product [the All-in-One Test]. I have had great success using MiDOG clinically, including identifying Mycoplasma in a 24 year old pigeon, a Nannizziopsis spp in a ball python from a large pet distributor, Mycoplasma and Fusobacterium necrophorum co-infection in a peacock, and to identify an abnormal gut GI in a technician’s dog that tested negative for everything else (but we were able to establish what was abnormal, and work toward fixing it).”

Dr. Jeremy Rayl – Veterinarian, Block House Creek Animal Hospital, Cedar Park, Texas